A Cold Plate Refrigeration System Optimized for Energy Efficiency is provided utilizing two refrigerant compressors and a single set of cold plates; or two refrigerant compressors, a conventional evaporator to air heat exchanger, and a single set of cold plates; or a single refrigerant compressor, a conventional evaporator to air heat exchanger, and a single set of cold plates. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure.