发明公开
EP2046336A2 3-ARYL-6-ARYL-7H-[1,2,4]TRIAZOLO[3,4-b][1,3,4]THIADIAZINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF
审中-公开
3-芳基-6-芳基 - 7H- [1,2,4]三唑并[3,4-b] [1,3,4]噻二嗪和类似物作为胱天蛋白酶的活化剂和细胞凋亡诱导剂及其用途
- 专利标题： 3-ARYL-6-ARYL-7H-[1,2,4]TRIAZOLO[3,4-b][1,3,4]THIADIAZINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF
- 专利标题（中）： 3-芳基-6-芳基 - 7H- [1,2,4]三唑并[3,4-b] [1,3,4]噻二嗪和类似物作为胱天蛋白酶的活化剂和细胞凋亡诱导剂及其用途
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申请号： EP07796912.9申请日： 2007-07-18
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公开(公告)号： EP2046336A2公开(公告)日： 2009-04-15
- 发明人: CAI, Sui Xiong , DREWE, John A. , ZHANG, Han-Zhong , KASIBHATLA, Shailaja , CLAASSEN, Gisela , SIRISOMA, Nilantha Sudath , KEMNITZER, William Edward
- 申请人： Cytovia, Inc.
- 申请人地址： 6650 Nancy Ridge Drive San Diego, CA 92121 US
- 专利权人： Cytovia, Inc.
- 当前专利权人： Cytovia, Inc.
- 当前专利权人地址： 6650 Nancy Ridge Drive San Diego, CA 92121 US
- 代理机构： Schlich, George William
- 优先权： US831458P 20060718; US879538P 20070110
- 国际公布： WO2008011045 20080124
- 主分类号： A61K31/53
- IPC分类号： A61K31/53 ; A61K31/542 ; A61K31/5365
摘要：
Disclosed are 3-aryl-6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and analogs thereof, represented by the Formula (I), wherein Ar1, Q2, R1, R2, dashed line and X are defined herein. The present invention relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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