发明公开
- 专利标题： CHIMERIC VIRUS VACCINES
- 专利标题（中）： 疫苗反对嵌合病毒
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申请号： EP07874444.8申请日： 2007-08-16
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公开(公告)号： EP2062246A2公开(公告)日： 2009-05-27
- 发明人: JOHNSTON, Robert, E. , JURGENS, Christy , YOUNG, Kelly
- 申请人： The University of North Carolina At Chapel Hill
- 申请人地址： 308 Bynum Hall, Campus Box 4105 Chapel Hill, NC 27599-4105 US
- 专利权人： The University of North Carolina At Chapel Hill
- 当前专利权人： The University of North Carolina At Chapel Hill
- 当前专利权人地址： 308 Bynum Hall, Campus Box 4105 Chapel Hill, NC 27599-4105 US
- 代理机构： Ward, Siobhan
- 优先权： US838604P 20060818; US840645P 20060828
- 国际公布： WO2008115199 20080925
- 主分类号： G09B19/00
- IPC分类号： G09B19/00
摘要：
The present invention provides novel self-replicating and self-propagating chimeric viral vectors and chimeric virus particles comprising a modified genome of a carrier RNA virus packaged within structural proteins of a second virus. Also provided are pharmaceutical formulations comprising the chimeric viral vectors and virus particles and methods of inducing an immune response by administration of the chimeric viral vectors and virus particles or nucleic acids (e.g., DNA and/or RNA) encoding the same to a subject.
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