发明授权
EP2066674B1 OCTAHYDROPYRROLO [3, 4-C] PYRROLE DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS
有权
八氢 - 吡咯并[3,4-C]吡咯和它们作为抗病毒剂的
- 专利标题： OCTAHYDROPYRROLO [3, 4-C] PYRROLE DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS
- 专利标题（中）： 八氢 - 吡咯并[3,4-C]吡咯和它们作为抗病毒剂的
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申请号： EP07803370.1申请日： 2007-09-10
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公开(公告)号： EP2066674B1公开(公告)日： 2010-06-30
- 发明人: LEMOINE, Remy , MELVILLE, Chris Richard , ROTSTEIN, David Mark , WANNER, Jutta
- 申请人： F.HOFFMANN-LA ROCHE AG
- 申请人地址： Grenzacherstrasse 124 4070 Basel CH
- 专利权人： F.HOFFMANN-LA ROCHE AG
- 当前专利权人： F.HOFFMANN-LA ROCHE AG
- 当前专利权人地址： Grenzacherstrasse 124 4070 Basel CH
- 代理机构： Zhuang Plodeck, Jianping
- 优先权： US845334P 20060918
- 国际公布： WO2008034731 20080327
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/407 ; A61P31/18
摘要：
Chemokine receptor antagonists, in particular, 3,7-diazabicyclo [3.3.0] octane compounds according to formula (I) wherein R1-R3 and Ar are as defined herein are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are alleviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula (I).
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