发明授权
- 专利标题： 5'-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS
- 专利标题（中）： 5'-改进双环的核酸类似物
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申请号： EP07797414.5申请日： 2007-05-10
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公开(公告)号： EP2066684B1公开(公告)日： 2012-07-18
- 发明人: SETH, Punit, P. , SWAYZE, Eric, E. , BALKRISHEN, Bhat
- 申请人： Isis Pharmaceuticals, Inc.
- 申请人地址： 2855 Gazelle Court Carlsbad, CA 92010 US
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： 2855 Gazelle Court Carlsbad, CA 92010 US
- 代理机构： Warner, James Alexander
- 优先权： US747059P 20060511
- 国际公布： WO2007134181 20071122
- 主分类号： C07H19/04
- IPC分类号： C07H19/04 ; C07H21/00
摘要：
The present invention provides 5'-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5'-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease resistance.
公开/授权文献
- EP2066684A2 5'-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS 公开/授权日：2009-06-10
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