发明公开
EP2069020A2 BENZO[D]ISOXAZOLE DERIVATIVES AS C-KIT TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH THE OVER PRODUCTION OF HISTAMINE
有权
苯并[d]异恶唑衍生物作为C-KIT酪氨酸激酶抑制剂用于生产组胺病例治疗疾病
- 专利标题： BENZO[D]ISOXAZOLE DERIVATIVES AS C-KIT TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH THE OVER PRODUCTION OF HISTAMINE
- 专利标题（中）： 苯并[d]异恶唑衍生物作为C-KIT酪氨酸激酶抑制剂用于生产组胺病例治疗疾病
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申请号： EP07810594.7申请日： 2007-07-18
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公开(公告)号： EP2069020A2公开(公告)日： 2009-06-17
- 发明人: CHEN, Ning , HU, Essa , KUNZ, Roxanne , RUMFELT, Shannon , TASKER, Andrew
- 申请人： Amgen Inc.
- 申请人地址： One Amgen Center Drive, M/S 28-2-C Thousand Oaks CA 93012 US
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： One Amgen Center Drive, M/S 28-2-C Thousand Oaks CA 93012 US
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权： US832306P 20060720
- 国际公布： WO2008011080 20080124
- 主分类号： A61P11/06
- IPC分类号： A61P11/06 ; C07D261/20 ; A61K31/42
摘要：
The present invention comprises a new class of compounds capable of modulating the c-kit protein kinase and, accordingly, useful for treatment of c-kit mediated diseases including, without limitation, autoimmune disease, allergies, mastocytosis, mast cell related tumors and various fibrotic diseases. The compounds have a general Formula (I) wherein R1-5, X, Y and Z are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
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