发明公开
EP2077330A1 Transgenic pig with altered incretin function and its uses for studying diabetes
审中-公开
转基因猪与改变Inkretinfunktion及其对糖尿病的研究用途
- 专利标题： Transgenic pig with altered incretin function and its uses for studying diabetes
- 专利标题（中）： 转基因猪与改变Inkretinfunktion及其对糖尿病的研究用途
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申请号： EP09000044.9申请日： 2009-01-05
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公开(公告)号： EP2077330A1公开(公告)日： 2009-07-08
- 发明人: Kessler, Barbara , Wanke, Rüdiger , Herbach, Nadja , Pfeifer, Alexander , Wolf, Eckhard , Renner, Simone , Hofmann, Andreas
- 申请人： MWM Biomodels GmbH , Ludwig-Maximilians-Universität
- 申请人地址： Hauptstrasse 41 84184 Tiefenbach DE
- 专利权人： MWM Biomodels GmbH,Ludwig-Maximilians-Universität
- 当前专利权人： MWM Biomodels GmbH,Ludwig-Maximilians-Universität
- 当前专利权人地址： Hauptstrasse 41 84184 Tiefenbach DE
- 代理机构： Engelhard, Markus
- 优先权： US19001P 20080104; EP08000111 20080104
- 主分类号： C12N15/85
- IPC分类号： C12N15/85 ; A01K67/027
摘要：
The present invention relates to transgenic pigs containing a dominant-negative incretin hormone receptor, namely the dominant-negative human glucose-dependent insulinotropic polypeptide receptor. The present invention furthermore relates to uses of these transgenic pigs as clinically relevant animal model systems for studying the pathogenesis and novel therapies for diabetes mellitus type 2, particularly for the maintenance and expansion of pancreatic β-cell mass.
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