In a method for sealing an incision in an interior body wall such as a gastrotomy opening in a stomach, a closure device (10) is positioned within the incision. The closure device includes a seal (12b) and an anchor (12a) coupled to the seal. The seal is positioned in sealing contact against a first surface surface of the body wall, and the anchor is positioned against the second surface of the body wall such that a portion of the closure device is positioned. The closure device seals the incision while healing takes place. Once the incision is significantly healed, the closure device bioerodes.