发明授权
EP2079743B1 PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER
有权
蝶啶AS POLO样激酶用于治疗癌症的抑制剂
- 专利标题: PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER
- 专利标题(中): 蝶啶AS POLO样激酶用于治疗癌症的抑制剂
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申请号: EP07824247.6申请日: 2007-10-19
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公开(公告)号: EP2079743B1公开(公告)日: 2012-01-25
- 发明人: MOFFAT, David Festus Charles , PATEL, Sanjay Ratilal , DAVIES, Stephen John , BAKER, Kenneth William John , PHILPS, Oliver James
- 申请人: Chroma Therapeutics Limited
- 申请人地址: 93 Milton Park Abingdon Oxon OX14 4RY GB
- 专利权人: Chroma Therapeutics Limited
- 当前专利权人: Chroma Therapeutics Limited
- 当前专利权人地址: 93 Milton Park Abingdon Oxon OX14 4RY GB
- 代理机构: Walls, Alan James
- 优先权: GB0621205 20061025; GB0715614 20070810
- 国际公布: WO2008050096 20080502
- 主分类号: C07D475/00
- IPC分类号: C07D475/00 ; A61K31/519 ; A61P35/00
摘要:
Compound of formula (I) are inhibitors of Polo-like kinases (PLKs), and are useful in treatment of cell proliferative diseases: wherein R1 and R2 are hydrogen, or an optionally substituted (C1-C6)alkyl, (C2- C6)alkenyl, (C2-C6)alkynyl or (C3-C6)cycloalkyl group; R3 and R3' are independently selected from hydrogen, -CN, hydroxyl, halogen, optionally substituted (C1-C6) alkyl, (C2- C6)alkenyl, (C2-C6)alkynyl or (C3-C6)cycloalkyl, -NR5R6 or C1-C4 alkoxy, wherein R5 and R6 are independently hydrogen or optionally substituted (C1-C6)alkyl; ring A is an optionally substituted mono- or bi-cyclic carbocyclic or heterocyclic ring or a ring system having up to 12 ring atoms; T is a radical of formula R-L1 -Y1- wherein R is an alpha amino acid or alpha amino acid ester motif, linked to ring A by linker R-L1-Y1- as defined in the claims.
公开/授权文献
信息查询
IPC分类:
C | 化学;冶金 |
C07 | 有机化学 |
C07D | 杂环化合物(高分子化合物入C08) |
C07D475/00 | 含蝶啶环系的杂环化合物 |