发明公开
- 专利标题： PROCESS FOR THE SULFINYLATION OF A PYRAZOLE DERIVATIVE
- 专利标题（中）： 一种吡唑衍生物的硫化方法
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申请号： EP07822222.1申请日： 2007-11-05
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公开(公告)号： EP2081909A1公开(公告)日： 2009-07-29
- 发明人: SUKOPP, Martin , KUHN, Oliver , GRÖNING, Carsten , KEIL, Michael , LONGLET, Jon J.
- 申请人： BASF SE
- 申请人地址： 67056 Ludwigshafen DE
- 专利权人： BASF SE
- 当前专利权人： BASF SE
- 当前专利权人地址： 67056 Ludwigshafen DE
- 优先权： US865178P 20061110; US913638P 20070424
- 国际公布： WO2008055879 20080515
- 主分类号： C07D231/44
- IPC分类号： C07D231/44 ; A01N43/56 ; A01N43/00 ; A61K31/415 ; A61P33/00
摘要：
The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent S in the presence of at least one amine acid complex wherein the amine(s) are selected from cyclic secondary amines and the acid(s) are selected from sulfonic acid derivatives, and with the addition of a halogenating agent, wherein S is [CF3S(O)]2O; or CF3S(O)X wherein X means fluoro, chloro, bromo, iodo, a hydroxy group, or an alkaline or alkaline earth metal salt of the hydroxy group; or mixtures thereof.
公开/授权文献
- EP2081909B8 PROCESS FOR THE SULFINYLATION OF A PYRAZOLE DERIVATIVE 公开/授权日：2013-02-20
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