发明授权
EP2093228B1 PYRROLINE-2-ONE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF
有权
吡咯啉-2-酮衍生物抗肿瘤坏死因子释放细胞，方法和应用
- 专利标题： PYRROLINE-2-ONE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF
- 专利标题（中）： 吡咯啉-2-酮衍生物抗肿瘤坏死因子释放细胞，方法和应用
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申请号： EP07816580.0申请日： 2007-10-16
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公开(公告)号： EP2093228B1公开(公告)日： 2012-02-22
- 发明人: ZHANG, Hesheng
- 申请人： Tianjin Hemay Bio-Tech Co., Ltd.
- 申请人地址： Xiao Yuan Xin Cun, 31-101 Teda Tianjin 300457 CN
- 专利权人： Tianjin Hemay Bio-Tech Co., Ltd.
- 当前专利权人： Tianjin Hemay Bio-Tech Co., Ltd.
- 当前专利权人地址： Xiao Yuan Xin Cun, 31-101 Teda Tianjin 300457 CN
- 代理机构： Korga, Leokadia
- 优先权： CN200610129420 20061115
- 国际公布： WO2008058449 20080522
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; C07D487/04 ; A61K31/4365 ; A61K31/437 ; A61P35/00 ; A61P31/00 ; A61P37/00 ; A61P9/00 ; A61P9/10 ; A61P5/00
摘要：
Compounds represented by formula (I) or (II) against cell releasing TNF α, their pharmaceutically acceptable salts or hydrates and preparation methods and uses thereof, in which A, B and E represent CH2, CO respectively; D represents S, NH, NC1-6 alkyl; R represents H, R3 ; R1 represents 1-4 same or different radical(s) selected from the group consisting of F, Cl, Br, C1-4 alkyl, OH, OC1-4 alkyl, NO2, NHC(O)C1-4 alkyl, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2; R2 represents F, CF3, H or C1-4 alkyl.
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