发明授权
EP2094638B1 2-ARYL-2-FLUOROPROPANOIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
有权
2-芳基-2- FLUOR丙烷羧酸及其衍生物，和含有药物组合物
- 专利标题： 2-ARYL-2-FLUOROPROPANOIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
- 专利标题（中）： 2-芳基-2- FLUOR丙烷羧酸及其衍生物，和含有药物组合物
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申请号： EP07859111.2申请日： 2007-12-18
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公开(公告)号： EP2094638B1公开(公告)日： 2012-08-08
- 发明人: ALLEGRETTI, Marcello , ARAMINI, Andrea , CESTA, Maria Candida
- 申请人： Dompe' S.P.A.
- 申请人地址： Località Campo di Pile snc 67100 L'Aquila IT
- 专利权人： Dompe' S.P.A.
- 当前专利权人： Dompe' S.P.A.
- 当前专利权人地址： Località Campo di Pile snc 67100 L'Aquila IT
- 代理机构： Sutto, Luca
- 优先权： EP06126496 20061219
- 国际公布： WO2008075184 20080626
- 主分类号： C07C59/88
- IPC分类号： C07C59/88 ; C07C233/11 ; C07C309/65 ; C07D277/42
摘要：
The present invention relates to (R,S) 2-aryl-2-fluoropropanoic acids, their single enantiomers (R) and (S), their derivatives amides and acylsulfonamides and to pharmaceutical compositions containing them, which are used in the prevention and treatment of tissue damage due to the exacerbated recruitment of polymorphonucleated neutrophils (PMN leukocytes) at inflammation sites. The present invention provides compounds for use in the treatment of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the treatment of damages caused by ischemia and reperfusion.
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