发明公开
EP2094686A1 5-{2-[4-(2-METHYL-5-QUINOLINYL)-L-PIPERIDINYL]ETHYL} QUINOLINONE DERIVATIVES AS 5HT1A RECEPTOR MODULATORS FOR TREATING SEXUAL DYSFUNCTION, COGNITION IMPAIREMENT, PSYCHOTIC DISORDERS, ANXIETY, DEPRESSION, ETC.
审中-公开
5- {2- [4-（2-甲基-5-喹啉基）-1-哌啶基]乙基}喹啉酮衍生物作为调制器用于治疗性功能障碍，认知障碍，精神病性精神障碍，焦虑症，抑郁症，等等。5HT1A受体
- 专利标题： 5-{2-[4-(2-METHYL-5-QUINOLINYL)-L-PIPERIDINYL]ETHYL} QUINOLINONE DERIVATIVES AS 5HT1A RECEPTOR MODULATORS FOR TREATING SEXUAL DYSFUNCTION, COGNITION IMPAIREMENT, PSYCHOTIC DISORDERS, ANXIETY, DEPRESSION, ETC.
- 专利标题（中）： 5- {2- [4-（2-甲基-5-喹啉基）-1-哌啶基]乙基}喹啉酮衍生物作为调制器用于治疗性功能障碍，认知障碍，精神病性精神障碍，焦虑症，抑郁症，等等。5HT1A受体
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申请号： EP07820489.8申请日： 2007-09-24
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公开(公告)号： EP2094686A1公开(公告)日： 2009-09-02
- 发明人: BERTANI, Barbara , BROMIDGE, Steven, Mark , GIANOTTI, Massimo , PASQUARELLO, Alessandra , ZUCCHELLI, Valeria
- 申请人： Glaxo Group Limited
- 申请人地址： Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN GB
- 专利权人： Glaxo Group Limited
- 当前专利权人： Glaxo Group Limited
- 当前专利权人地址： Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN GB
- 代理机构： Sewell, Richard Charles
- 优先权： GB0618949 20060926; GB0712147 20070622
- 国际公布： WO2008037681 20080403
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D401/14 ; C07D487/08 ; A61K31/496
摘要：
The invention provides compounds of formula (I) wherein R1 is C1-6alkyl, halo or haloC1-6alkyl; R2 is hydrogen or C1-6alkyl; ===== is a single or double bond; each R3 and R4, which may be the same or different, are hydrogen, C1-6alkyl or haloC1-6alkyl; wherein i) when ===== is a double bond p and q are 1, and ii) when ===== is a single bond, p and q are 2, and one of R3 and one of R4 together with their interconnecting atoms, forms a cyclopropane ring which may be substituted by one or two halo or methyl groups, which groups may be the same or different; X is CH or N; when present each R5, which may be the same or different, is C1-6alkyl or halo; or two R5 groups may join to form a bridge, which bridge contains one or two atoms; n is 0, 1, 2 or 3; when present each R6 which may be the same or different, is C1-6alkyl or halo; and m is 0, 1, 2 or 3.
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