发明公开
- 专利标题： NOUVEAUX DERIVES IMIDAZOLONES, LEUR PREPARATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES, UTILISATION COMME INHIBITEURS DE PROTEINES KINASES NOTAMMENT CDC7
- 专利标题（英）： New imidazolone derivatives, preparation thereof as drugs, pharmaceutical compositions, and use thereof as protein kinase inhibitors, in particular cdc7
- 专利标题（中）： 新的咪唑啉衍生物积极的准备，其药物组合物及其作为蛋白激酶抑制剂，特别是CDC7
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申请号： EP07858418.2申请日： 2007-10-10
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公开(公告)号： EP2094699A2公开(公告)日： 2009-09-02
- 发明人: LEROY, Vincent , BACQUE, Eric , CONSEILLER, Emmanuel , STEINMETZ, Anke , RONAN, Baptiste , LETALLEC, Jean-Philippe
- 申请人： Sanofi-Aventis
- 申请人地址： 174 Avenue de France 75013 Paris FR
- 专利权人： Sanofi-Aventis
- 当前专利权人： Sanofi-Aventis
- 当前专利权人地址： 174 Avenue de France 75013 Paris FR
- 代理机构： Kugel, Dominique
- 优先权： FR0608924 20061012
- 国际公布： WO2008046982 20080424
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437 ; A61P35/00
摘要：
The invention relates to products of the formula (I) in which : X-Y is NH-C(S), N=C-NR7R8, N=C-SR, N=C-R or N=C-OR; R and R1 are H or optionally substituted cycloalkyl, alkyl, heterocycloalkyl, aryl or heteroaryl,; R2 is H, Hal or alkyl; R3 is H, Hal, OH, alkyl or alkoxy; R4 is H, Hal, CN or alkyl; R5 is essentially H, Hal, OH, NR7R8, cycloalkyl, alkyl, alkoxy, heterocycloalkyl, aryl or heteroaryl, optionally substituted; R6 is H, Hal, OH, NH2, NHalk, N(alk)2, alkyl or alkoxy; with R7 et R8 being such that one is H or optionally substituted alk, while the other is H or optionally substituted cycloalkyl, alkyl, heterocycloalkyl, heteroaryl or aryl; or with R7 and R8 forming together with N an optionally substituted cyclic radical optionally containing O, S or N. The invention also relates to isomers and salts thereof used as drugs and essentially as protein kinase inhibitors, in particular CDC7.
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