发明授权
EP2104535B1 COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS
有权
化合物和组合物的通道活化蛋白酶抑制剂
- 专利标题： COMPOUNDS AND COMPOSITIONS AS CHANNEL ACTIVATING PROTEASE INHIBITORS
- 专利标题（中）： 化合物和组合物的通道活化蛋白酶抑制剂
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申请号： EP07854747.8申请日： 2007-11-21
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公开(公告)号： EP2104535B1公开(公告)日： 2010-12-29
- 发明人: TULLY, David C. , CHATTERJEE, Arnab K. , VIDAL, Agnes , BURSULAYA, Badry , SPRAGGON, Glen
- 申请人： IRM LLC
- 申请人地址： 131 Front Street P.O. Box HM 2899 Hamilton HM LX BM
- 专利权人： IRM LLC
- 当前专利权人： IRM LLC
- 当前专利权人地址： 131 Front Street P.O. Box HM 2899 Hamilton HM LX BM
- 代理机构： Kiddle, Simon John
- 优先权： US884334P 20070110; US891474P 20070223
- 国际公布： WO2008085608 20080717
- 主分类号： A61P11/00
- IPC分类号： A61P11/00 ; A61K31/425 ; A61P11/06 ; A61K31/444 ; A61P11/08 ; C07K5/06 ; A61K31/401 ; A61P29/00
摘要：
The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.
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