发明公开
EP2111389A1 VERFAHREN ZUR HERSTELLUNG SUBSTITUIERTER 2-ARYLMALONSÄUREESTER
审中-公开
生产工艺取代的2-ARYLMALONSÄUREESTER
- 专利标题: VERFAHREN ZUR HERSTELLUNG SUBSTITUIERTER 2-ARYLMALONSÄUREESTER
- 专利标题(英): Method for the production of substituted 2-aryl malonic acid esters
- 专利标题(中): 生产工艺取代的2-ARYLMALONSÄUREESTER
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申请号: EP08701608.5申请日: 2008-01-21
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公开(公告)号: EP2111389A1公开(公告)日: 2009-10-28
- 发明人: MAYWALD, Volker , OTT, Christian , WOLF, Bernd , EHRESMANN, Manfred , RACK, Michael , KEIL, Michael , SMIDT, Sebastian, Peer
- 申请人: BASF SE
- 申请人地址: 67056 Ludwigshafen DE
- 专利权人: BASF SE
- 当前专利权人: BASF SE
- 当前专利权人地址: 67056 Ludwigshafen DE
- 优先权: EP07100926 20070122
- 国际公布: WO2008090127 20080731
- 主分类号: C07C67/343
- IPC分类号: C07C67/343 ; C07C69/65 ; C07C17/12 ; C07C25/13
摘要:
The present invention relates to a method for the production of substituted 2-aryl malonic acid esters of the general formula (I), wherein R stands for C1-C6-alkyl or C1-C4-alkoxy-C1-C4-alkyl; Ar stands for phenyl or a heteroaromatic 5-member or 6-member ring; wherein each C atom contained in the above-named groups potentially carries a substituent RA; RA stands for F, C1, CN, NO2, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, etc., or two adjacent substituents RA form a ring together with the carbon atoms to which they are bound; and wherein a malonic acid ester is converted with a base and an aryl bromide in the presence of a copper salt, characterized in that 0.1 to 0.65 mole equivalents of the base are substituted for 1 mole equivalent of the malonic acid ester.
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