发明公开
EP2112220A2 Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences
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HerstellungabgeschwächterImpfstoffe gegen das respiratorische Synzytialvirus aus geklonten Nukleotidsequenzen
- 专利标题： Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences
- 专利标题（中）： HerstellungabgeschwächterImpfstoffe gegen das respiratorische Synzytialvirus aus geklonten Nukleotidsequenzen
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申请号： EP09157028.3申请日： 1997-07-15
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公开(公告)号： EP2112220A2公开(公告)日： 2009-10-28
- 发明人: Murphy, Brian , Collins, Peter , Whitehead, Stephen , Bukreyev, Alexander , Juhasz, Katalin , Teng, Michael
- 申请人： The Government of the United States of America, as represented by The Department of Health and Human Services
- 申请人地址： Box OTT Bethesda, MD 20892 US
- 专利权人： The Government of the United States of America, as represented by The Department of Health and Human Services
- 当前专利权人： The Government of the United States of America, as represented by The Department of Health and Human Services
- 当前专利权人地址： Box OTT Bethesda, MD 20892 US
- 代理机构： Suèr, Steven Johannes
- 优先权： US47634P 19970523; US46141P 19970509; US21773P 19960715
- 主分类号： C12N7/04
- IPC分类号： C12N7/04 ; C12N7/01 ; A61K39/155 ; C12N15/45 ; C12N7/00
摘要：
Attenuated respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing specific mutations associated with attenuating phenotypes into wild-type or RSV which is incompletely attenuated by cold-passage or introduction of mutations which produce virus having a temperature sensitive (ts) or cold adapted (ca) phenotype. Alternatively, recombinant RSV and vaccine compositions thereof incorporate attenuating and other mutations specifying desired structural and or phenotypic characteristics in an infectious RSV. Recombinant RSV incorporate desired mutations specified by insertion, deletion, substitution or rearrangement of a selected nucleotide sequence, gene, or gene segment in an infectious RSV clone. The immune system of an individual is stimulated to induce protection against natural RSV infection, or multivalently against infection by RSV and another pathogen, such as PlV, by administration of attenuated, biologically derived or recombinant RSV.
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