A patient interface includes a body portion configured to communicate with at least one fluid path, and at least one nostril interface extending from the body portion. The nostril interface includes an insertion portion configured to be inserted into a nostril of a patient and to be in communication with the at least one fluid path. In an embodiment, the insertion portion includes a plurality of laterally directed openings configured to communicate fluid between the fluid path and the nostril. The patient interface also includes a seal portion that is constructed and arranged to provide a seal between the patient interface and the nostril.