发明公开
- 专利标题: NOVEL PHOSPHODIESTERASE INHIBITORS
- 专利标题(中): 新型磷酸二酯酶抑制剂
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申请号: EP08706922.5申请日: 2008-02-26
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公开(公告)号: EP2114951A2公开(公告)日: 2009-11-11
- 发明人: Felding, Jakob , Nielsen, Simon, Feldbaek , Larsen, Jens, Christian, Hojland , Babu, Bollu, Ravindra
- 申请人: LEO PHARMA A/S
- 申请人地址: Industriparken 55 2750 Ballerup DK
- 专利权人: LEO PHARMA A/S
- 当前专利权人: LEO PHARMA A/S
- 当前专利权人地址: Industriparken 55 2750 Ballerup DK
- 代理机构: Thalsoe-Madsen, Kine Birgit
- 优先权: US903849P 20070228; US946849P 20070628
- 国际公布: WO2008104175 20080904
- 主分类号: C07D491/10
- IPC分类号: C07D491/10 ; C07D493/10 ; C07D495/10 ; A61K31/36 ; A61P29/00
摘要:
The present invention relates to a compound according to formula I, wherein X, A, G, E, R1, R2, R3 are as shown herein; and pharmaceutically acceptable salts, hydrates, N- oxides or solvates hereof, said compounds are used as phoshodiesterase inhibitors in particular PDE4 inhibitors. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.
公开/授权文献
- EP2114951B9 NOVEL PHOSPHODIESTERASE INHIBITORS 公开/授权日:2015-09-02
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