发明公开
EP2117573A2 COMPOSITIONS AND METHODS FOR TREATING CONDITIONS RELATED TO EPHRIN SIGNALING WITH CUPREDOXINS AND MUTANTS THEREOF
审中-公开
组合物和方法治疗EPHRINSIGNALISIERUNG与CUPREDOXINEN及其突变体
- 专利标题： COMPOSITIONS AND METHODS FOR TREATING CONDITIONS RELATED TO EPHRIN SIGNALING WITH CUPREDOXINS AND MUTANTS THEREOF
- 专利标题（中）： 组合物和方法治疗EPHRINSIGNALISIERUNG与CUPREDOXINEN及其突变体
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申请号： EP08727595.4申请日： 2008-01-11
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公开(公告)号： EP2117573A2公开(公告)日： 2009-11-18
- 发明人: CHAUDHARI, Anita , CHAKRABARTY, Ananda , DAS GUPTA, Tapas , FIALHO, Arsenio , YAMADA, Tohru , ZHU, Yonghua
- 申请人： The Board Of Trustees Of The University Of Illinois
- 申请人地址： 352 Henry Administration Building 506 South Wright Street Urbana, IL 68101 US
- 专利权人： The Board Of Trustees Of The University Of Illinois
- 当前专利权人： The Board Of Trustees Of The University Of Illinois
- 当前专利权人地址： 352 Henry Administration Building 506 South Wright Street Urbana, IL 68101 US
- 代理机构： Becker, Philippe
- 优先权： US879804P 20070111
- 国际公布： WO2008086523 20080717
- 主分类号： A61K38/00
- IPC分类号： A61K38/00
摘要：
The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system in mammalian cells. Specifically, the invention relates to compositions and methods that use cupredoxins, such as azurin, rusticyanin and plastocyanin, and variants, derivatives and structural equivalents thereof, to treat cancer in mammals. The invention specifically includes mutants with altered Eph binding constants and selectivities.
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