发明公开
- 专利标题: QUATERNARY AMMONIUM DIPHENYLMETHYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS
- 专利标题(中): 季铵化合物AS二苯毒蕈碱受体拮抗剂
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申请号: EP08725911.5申请日: 2008-02-21
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公开(公告)号: EP2121594A1公开(公告)日: 2009-11-25
- 发明人: JI, Yu-hua , HUSFELD, Craig , LANGE, Christopher , LEE, Rick , MU, Yongqi
- 申请人: Theravance, Inc.
- 申请人地址: 901 Gateway Boulevard South San Francisco, CA 94080 US
- 专利权人: Theravance, Inc.
- 当前专利权人: Theravance, Inc.
- 当前专利权人地址: 901 Gateway Boulevard South San Francisco, CA 94080 US
- 代理机构: Scott, Susan Margaret
- 优先权: US903110P 20070223
- 国际公布: WO2008103426 20080828
- 主分类号: C07D207/08
- IPC分类号: C07D207/08 ; C07D207/09 ; A61K31/40 ; A61P11/00
摘要:
The invention provides compounds of formula (I) in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R 1-6, a-e and Q are as defined in the specification,. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
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