发明公开
EP2123298A1 AGENT FOR SUPPRESSING REJECTION IN ORGAN TRANSPLANTATION COMPRISING ANTI-HMGB-1 ANTIBODY
审中-公开
手段排斥具有抗HMGB-1抗体器官移植还原
- 专利标题： AGENT FOR SUPPRESSING REJECTION IN ORGAN TRANSPLANTATION COMPRISING ANTI-HMGB-1 ANTIBODY
- 专利标题（中）： 手段排斥具有抗HMGB-1抗体器官移植还原
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申请号： EP08711350.2申请日： 2008-02-15
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公开(公告)号： EP2123298A1公开(公告)日： 2009-11-25
- 发明人: YASUNAMI, Yohichi , MARUYAMA, Ikuro , YAMADA, Shingo
- 申请人： Fukuoka University , Kagoshima University , SHINO-TEST CORPORATION
- 申请人地址： 19-1, Nanakuma 8-chome Junan-ku, Fukuoka-shi Fukuoka 814-0180 JP
- 专利权人： Fukuoka University,Kagoshima University,SHINO-TEST CORPORATION
- 当前专利权人： Fukuoka University,Kagoshima University,SHINO-TEST CORPORATION
- 当前专利权人地址： 19-1, Nanakuma 8-chome Junan-ku, Fukuoka-shi Fukuoka 814-0180 JP
- 代理机构： Vossius & Partner
- 优先权： JP2007034280 20070215
- 国际公布： WO2008099917 20080821
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61P37/06
摘要：
An objective of the present invention is to provide effective methods for suppressing rejection in organ transplantation, in particular, pancreatic islet transplantation which is useful in treating diabetes. The present invention demonstrated that antibodies against HMGB-1 suppressed the rejection in pancreatic islet transplantation and promoted the survival of grafted pancreatic islets. Thus, the present invention provides agents that comprise an anti-HMGB-1 antibody for suppressing rejection in organ transplantation.
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