发明公开
EP2124974A2 GLUCAGON ANALOGS EXHIBITING ENHANCED SOLUBILITY IN PHYSIOLOGICAL PH BUFFERS
有权
具有增加的溶解度，生理pH缓冲剂GLOCAGONANALOGA
- 专利标题： GLUCAGON ANALOGS EXHIBITING ENHANCED SOLUBILITY IN PHYSIOLOGICAL PH BUFFERS
- 专利标题（中）： 具有增加的溶解度，生理pH缓冲剂GLOCAGONANALOGA
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申请号： EP08713455.7申请日： 2008-01-03
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公开(公告)号： EP2124974A2公开(公告)日： 2009-12-02
- 发明人: DIMARCHI, Richard, D. , DIMARCHI, Maria , CHABENNE, Joseph
- 申请人： Indiana University Research and Technology Corporation
- 申请人地址： 351 West 10th Street Indianapolis, IN 46202 US
- 专利权人： Indiana University Research and Technology Corporation
- 当前专利权人： Indiana University Research and Technology Corporation
- 当前专利权人地址： 351 West 10th Street Indianapolis, IN 46202 US
- 代理机构： Ponti Sales, Adelaida
- 优先权： US878919P 20070105
- 国际公布： WO2008086086 20080717
- 主分类号： A61K35/37
- IPC分类号： A61K35/37 ; A61K35/38 ; C07K14/605
摘要：
Modified glucagon peptides are disclosed having improved solubility while retaining glucagon agonist activity. The glycogen peptides have been modified by substitution of native amino acids with, and/or addition of, charged amino acids to the carboxy terminus of the peptide. The modified glucagon agonists can be further modified by pegylation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 23, or both to further enhance the solubility of the glucagon agonist analogs.
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