发明公开
EP2125894A2 BINDING PROTEINS, INCLUDING ANTIBODIES, ANTIBODY DERIVATIVES AND ANTIBODY FRAGMENTS, THAT SPECIFICALLY BIND CD154 AND USES THEREOF
审中-公开
结合蛋白的抗体，抗体衍生物和抗体片段与特异性结合CD154及其用途
- 专利标题： BINDING PROTEINS, INCLUDING ANTIBODIES, ANTIBODY DERIVATIVES AND ANTIBODY FRAGMENTS, THAT SPECIFICALLY BIND CD154 AND USES THEREOF
- 专利标题（中）： 结合蛋白的抗体，抗体衍生物和抗体片段与特异性结合CD154及其用途
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申请号： EP08742182.2申请日： 2008-03-21
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公开(公告)号： EP2125894A2公开(公告)日： 2009-12-02
- 发明人: BURKLY, Linda C. , FERRANT-ORGETTAS, Janine L. , GARBER, Ellen A. , HSU, Yen-ming , SU, Lihe , TAYLOR, Frederick R. , ADAMS, Ralph , BROWN, Derek Thomas , POPPLEWELL, Andrew George , ROBINSON, Martyn Kim , SHOCK, Anthony , TYSON, Kerry Louise
- 申请人： Biogen Idec MA, Inc. , UCB Pharma, S.A.
- 申请人地址： 14 Cambridge Center Cambridge Massachusetts 02142 US
- 专利权人： Biogen Idec MA, Inc.,UCB Pharma, S.A.
- 当前专利权人： Biogen Idec MA, Inc.,UCB Pharma, S.A.
- 当前专利权人地址： 14 Cambridge Center Cambridge Massachusetts 02142 US
- 代理机构： Adams, Harvey Vaughan John
- 优先权： US919816P 20070322; US919938P 20070322; US920495P 20070327
- 国际公布： WO2008118356 20081002
- 主分类号： C07K16/28
- IPC分类号： C07K16/28
摘要：
This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.
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