发明授权
- 专利标题： METHOD FOR PRODUCING 2-NITROIMIDAZOLE DERIVATIVE
- 专利标题（中）： 用于生产2-硝基咪唑衍生物
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申请号： EP08702779.3申请日： 2008-01-17
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公开(公告)号： EP2128140B1公开(公告)日： 2012-03-14
- 发明人: NISHIO, Azuma
- 申请人： Pola Pharma Inc.
- 申请人地址： 8-9-5, Nishigotanda Shinagawa-ku Tokyo 141-0031 JP
- 专利权人： Pola Pharma Inc.
- 当前专利权人： Pola Pharma Inc.
- 当前专利权人地址： 8-9-5, Nishigotanda Shinagawa-ku Tokyo 141-0031 JP
- 代理机构： Blodig, Wolfgang
- 优先权： JP2007012147 20070123
- 国际公布： WO2008090731 20080731
- 主分类号： C07D233/91
- IPC分类号： C07D233/91 ; A61K51/00
摘要：
Disclosed is a method for producing a 2-nitroimidazole derivative having an acyclic sugar chain in a side chain which is suitable for production of a derivative having a radioisotope. Specifically disclosed is a method for producing 1-(1- benzoyloxymethyl-2-hydroxyethyl)oxymethyl-2-nitroimidazole, which is characterized in that 1-O-benzoylglycerin is obtained by reacting glycerin with a benzoylating agent, then 4-benzoyloxymethyl-1,3-dioxolane is obtained by reacting 1-O-benzoylglycerin with dimethoxymethane in the presence of a dehydrating agent, and then 4-benzoyloxymethyl-1,3-dioxolane is reacted with 2-nitroimidazole or 2-nitro-1-trialkylsilylimidazole in the presence of a Lewis acid.
公开/授权文献
- EP2128140A1 METHOD FOR PRODUCING 2-NITROIMIDAZOLE DERIVATIVE 公开/授权日：2009-12-02
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