发明公开
EP2132155A1 METHOD OF PRODUCING AN OPTICALLY ACTIVE CYANOHYDRIN DERIVATIVE
审中-公开
工艺制备光学活性CYANOHYDRINDERIVATS
- 专利标题： METHOD OF PRODUCING AN OPTICALLY ACTIVE CYANOHYDRIN DERIVATIVE
- 专利标题（中）： 工艺制备光学活性CYANOHYDRINDERIVATS
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申请号： EP07716169.3申请日： 2007-03-29
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公开(公告)号： EP2132155A1公开(公告)日： 2009-12-16
- 发明人: YEO, Wee Chuan , CHAI, L. L. Christina , SELVARATNAM, Selvasothi , NAGATA, Takushi , YOSHINAGA, Kazuhiko
- 申请人： Agency for Science, Technology and Research , Mitsui Chemicals, Inc.
- 申请人地址： 1 Fusionopolis Way No 20-10 Connexis Singapore 138632 SG
- 专利权人： Agency for Science, Technology and Research,Mitsui Chemicals, Inc.
- 当前专利权人： Agency for Science, Technology and Research,Mitsui Chemicals, Inc.
- 当前专利权人地址： 1 Fusionopolis Way No 20-10 Connexis Singapore 138632 SG
- 代理机构： Viering, Jentschura & Partner
- 国际公布： WO2008121074 20081009
- 主分类号： C07B53/00
- IPC分类号： C07B53/00 ; C07B43/08 ; C07B41/02 ; C07C253/00
摘要：
The present invention relates to a method of producing an optically active cyanohydrin derivative, which comprises reacting an aldehyde or an asymmetrical ketone with a cyanating agent in the presence of a Lewis base and a titanium compound produced from a partial hydrolysate of titanium tetraalkoxide and an optically active ligand represented by formula (II) or a titanium oxoalkoxide compound represented by formula (I) [TixOy](OR1)4x-2y, and an optically active ligand represented by formula (II), wherein R1 is an optionally substituted alkyl group or an optionally substituted aryl group; x is an integer of not less than 2; y is an integer of not less than 1; and y/x satisfies 0.1
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