发明公开
EP2141153A3 Stereoselective alkylation of chiral 2-methyl-4 protected piperazines
审中-公开
手性2-甲基-4-哌嗪保护的立体选择性烷基化
- 专利标题： Stereoselective alkylation of chiral 2-methyl-4 protected piperazines
- 专利标题（中）： 手性2-甲基-4-哌嗪保护的立体选择性烷基化
-
申请号： EP09013102.0申请日： 2003-03-27
-
公开(公告)号： EP2141153A3公开(公告)日： 2010-05-26
- 发明人: Wu, Wenxue , Liao, Hongbiao , Tsai, David, J. , Andrews, David, R. , Gala, Dinesh , Lee, Gary, M , Schwartz, Martin, Lawrence , McAllister, Timothy, L. , Fu, Xiaoyong , Maloney, Donal , Thiruvengadam, T., K. , Tann, Chou-Hang
- 申请人： Schering Corporation
- 申请人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033-0530 US
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033-0530 US
- 代理机构： UEXKÜLL & STOLBERG
- 优先权： US368707P 20020329
- 主分类号： C07D241/04
- IPC分类号： C07D241/04
摘要：
The invention relates to a process for selectively preparing a mono-4-protected 2-methylpiperazine from its corresponding 2-methylpiperazine in high yields, said process comprising reacting said 2-methylpiperazine with about a molar equivalent of a protecting reagent in a solvent, with the reaction being catalyzed by an acid catalyst or a base catalyst.
公开/授权文献
信息查询
