发明公开
EP2141227A3 Hyperblebbing bacterial strains and use thereof for production of vaccines
审中-公开
Hyperblebbing“细菌菌株及其对疫苗的制备使用
- 专利标题： Hyperblebbing bacterial strains and use thereof for production of vaccines
- 专利标题（中）： Hyperblebbing“细菌菌株及其对疫苗的制备使用
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申请号： EP09165364.2申请日： 2002-02-08
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公开(公告)号： EP2141227A3公开(公告)日： 2010-08-11
- 发明人: Berthet, Francois-Xavier Jacques , Denoel, Philippe , Neyt, Cecile Anne , Poolman, Jan , Thonnard, Joelle
- 申请人： SmithKline Beecham Biologicals S.A.
- 申请人地址： Rue de l'Institut 89 1330 Rixensart DE
- 专利权人： SmithKline Beecham Biologicals S.A.
- 当前专利权人： SmithKline Beecham Biologicals S.A.
- 当前专利权人地址： Rue de l'Institut 89 1330 Rixensart DE
- 代理机构： Lubienski, Michael John
- 优先权： GB0103171 20010208
- 主分类号： C12N1/21
- IPC分类号： C12N1/21 ; C07K14/22 ; C07K14/285 ; C07K14/195 ; A61K39/095 ; A61K39/10 ; A61K39/102 ; A61K39/104 ; A61K39/106
摘要：
The present invention relates to the field of, engineered Gram-negative bacterial strains that have outer-membrane vesicle shedding properties, and vaccine compositions comprising these bacteria or vesicles. The present invention provides a hyperblebbing Gram-negative bacterium which has been genetically modified by either or both processes selected from a group consisting of: down- regulation of expression of one or more tol genes; and mutation of one or more gene(s) encoding a protein comprising a peptidoglycan-associated site to attenuate the peptidoglycan-binding activity of the protein(s).
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