发明公开
EP2142535A2 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES
审中-公开
3- IMIDAZOLYLINDOLE用于治疗增殖性疾病
- 专利标题： 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES
- 专利标题（中）： 3- IMIDAZOLYLINDOLE用于治疗增殖性疾病
-
申请号： EP08735532.7申请日： 2008-03-27
-
公开(公告)号： EP2142535A2公开(公告)日： 2010-01-13
- 发明人: BOETTCHER, Andreas , BUSCHMANN, Nicole , FURET, Pascal , GROELL, Jean-Marc , KALLEN, Jörg , HERGOVICH LISZTWAN, Joanna , MASUYA, Keiichi , MAYR, Lorenz , VAUPEL, Andrea
- 申请人： Novartis AG
- 申请人地址： Lichtstrasse 35 4056 Basel CH
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： Lichtstrasse 35 4056 Basel CH
- 代理机构： Vögeli-Lange, Regina
- 优先权： EP07105269 20070329
- 国际公布： WO2008119741 20081009
- 主分类号： C07D403/04
- IPC分类号： C07D403/04 ; A61K31/4164 ; A61P35/00
摘要：
The invention relates to 3-heterocyclyl indolyl compounds capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, said compounds having the formula (I) wherein R1, R2, R3, R4, RA, Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.
信息查询
