发明公开
EP2149561A1 TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF
有权
四氢番茄红素1-ON-DERIVAT ODER SALZ DARAUS
- 专利标题： TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF
- 专利标题（中）： 四氢番茄红素1-ON-DERIVAT ODER SALZ DARAUS
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申请号： EP08764654.3申请日： 2008-05-26
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公开(公告)号： EP2149561A1公开(公告)日： 2010-02-03
- 发明人: HISAMICHI, Hiroyuki , SHIMADA, Itsuro , ISHIHARA, Tsukasa , TAKUWA, Tomofumi , SHIMIZU, Takafumi , ISHIKAWA, Noriko , MAENO, Kyoichi , SEKI, Norio
- 申请人： Astellas Pharma Inc.
- 申请人地址： 3-11, Nihonbashi-Honcho 2-chome Chuo-ku Tokyo 103-8411 JP
- 专利权人： Astellas Pharma Inc.
- 当前专利权人： Astellas Pharma Inc.
- 当前专利权人地址： 3-11, Nihonbashi-Honcho 2-chome Chuo-ku Tokyo 103-8411 JP
- 代理机构： Gille Hrabal Struck Neidlein Prop Roos
- 优先权： JP2007140097 20070528
- 国际公布： WO2008146774 20081204
- 主分类号： C07D217/26
- IPC分类号： C07D217/26 ; A61K31/472 ; A61K31/496 ; A61K31/497 ; A61K31/501 ; A61K31/506 ; A61K31/53 ; A61K31/5377 ; A61K31/695 ; A61P1/00 ; A61P35/00 ; C07D401/04 ; C07D401/06 ; C07D401/12 ; C07D405/04 ; C07D405/06 ; C07D405/14 ; C07D409/12 ; C07D413/12 ; C07D417/12
摘要：
[Problems] To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS).
[Means for Solving Problems] It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.
[Means for Solving Problems] It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.
公开/授权文献
- EP2149561B1 TETRAHYDROISOQUINOLIN-1-ONE DERIVATIVE OR SALT THEREOF 公开/授权日：2015-09-09
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