发明公开
EP2152287A2 METHODS FOR TREATING AND PREVENTING GI SYNDROME AND GRAFT VERSUS HOST DISEASE
有权
VERFAHREN ZUR BEHANDLUNG UND PRAVENTION VON GI-SYNDROM UND TRANSPLANTATABSTOSSUNG
- 专利标题： METHODS FOR TREATING AND PREVENTING GI SYNDROME AND GRAFT VERSUS HOST DISEASE
- 专利标题（中）： VERFAHREN ZUR BEHANDLUNG UND PRAVENTION VON GI-SYNDROM UND TRANSPLANTATABSTOSSUNG
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申请号： EP08755086.9申请日： 2008-05-06
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公开(公告)号： EP2152287A2公开(公告)日： 2010-02-17
- 发明人: ROTOLO, Jimmy , KOLESNICK, Richard , PASQUALINI, Renate , ARAP, Wadih
- 申请人： Sloan Kettering Institute For Cancer Research
- 申请人地址： Memorial Sloan Kettering Cancer Center Office of Industrial Affairs 1275 York Avenue New York, New York 10021 US
- 专利权人： Sloan Kettering Institute For Cancer Research
- 当前专利权人： Sloan Kettering Institute For Cancer Research
- 当前专利权人地址： Memorial Sloan Kettering Cancer Center Office of Industrial Affairs 1275 York Avenue New York, New York 10021 US
- 代理机构： Chapman, Paul Gilmour
- 优先权： US916298P 20070506
- 国际公布： WO2008137901 20081113
- 主分类号： A61K38/00
- IPC分类号： A61K38/00
摘要：
We have discovered that administering anti-ceramide antibody treats and prevents an array of diseases mediated by cytolytic T lymphocyte (CTLs)-induced killing and by damage to endothelial microvasculture, including radiation-induced GI syndrome, Graft vs. Host diseases, inflammatory diseases and autoimmune diseases. We have also discovered new anti-ceramide monoclonal antibodies, that have therapeutic use preferably in humanized form to treat or prevent these diseases.
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