发明公开
EP2152719A1 BICYCLIC HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE
审中-公开
双环杂芳族化合物作为抑制剂硬脂酰辅酶A DELTA-9脱氢酶
- 专利标题： BICYCLIC HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE
- 专利标题（中）： 双环杂芳族化合物作为抑制剂硬脂酰辅酶A DELTA-9脱氢酶
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申请号： EP08748339.2申请日： 2008-05-22
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公开(公告)号： EP2152719A1公开(公告)日： 2010-02-17
- 发明人: LEGER, Serge , DESCHENES, Denis , FORTIN, Rejean , ISABEL, Elise , POWELL, David
- 申请人： Merck Frosst Canada Ltd.
- 申请人地址： 16711 Trans-Canada Highway Kirkland, Québec H9H 3L1 CA
- 专利权人： Merck Frosst Canada Ltd.
- 当前专利权人： Merck Frosst Canada Ltd.
- 当前专利权人地址： 16711 Trans-Canada Highway Kirkland, Québec H9H 3L1 CA
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US931460P 20070523
- 国际公布： WO2008141455 20081127
- 主分类号： C07D513/04
- IPC分类号： C07D513/04 ; A61K31/519 ; A61K31/522 ; A61P3/00 ; C07D473/30 ; C07D498/04
摘要：
Bicyclic heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).
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