发明公开
EP2154962A1 PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS
审中-公开
苯基邻苯二甲酰胺单甲氧基甲硅烷氧基丙烯酸酯
- 专利标题： PHENYL SUBSTITUTED CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS
- 专利标题（中）： 苯基邻苯二甲酰胺单甲氧基甲硅烷氧基丙烯酸酯
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申请号： EP08756635.2申请日： 2008-06-02
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公开(公告)号： EP2154962A1公开(公告)日： 2010-02-24
- 发明人: SHAO, Liming , WANG, Fengjiang , MALCOLM, Scott, Christopher , HEWITT, Michael, Charles , MA, Jianguo , RIBE, Seth , VARNEY, Mark, A. , CAMPBELL, Una , ENGEL, Sharon, Rae , HARDY, Larry, Wendell , KOCH, Patrick , SCHREIBER, Rudy , SPEAR, Kerry, L.
- 申请人： Sepracor Inc.
- 申请人地址： 84 Waterford Drive Marlborough, Massachusetts 01752-7010 US
- 专利权人： Sepracor Inc.
- 当前专利权人： Sepracor Inc.
- 当前专利权人地址： 84 Waterford Drive Marlborough, Massachusetts 01752-7010 US
- 代理机构： Harrison Goddard Foote
- 优先权： US941242P 20070531
- 国际公布： WO2008151156 20081211
- 主分类号： A01N43/00
- IPC分类号： A01N43/00
摘要：
Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g. from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.
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