发明公开
EP2155777A2 SOLUBLE AND MEMBRANE-ANCHORED FORMS OF LASSA VIRUS SUBUNIT PROTEINS
审中-公开
可溶性蛋白和膜蛋白停泊形式的病毒拉沙单位
- 专利标题： SOLUBLE AND MEMBRANE-ANCHORED FORMS OF LASSA VIRUS SUBUNIT PROTEINS
- 专利标题（中）： 可溶性蛋白和膜蛋白停泊形式的病毒拉沙单位
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申请号： EP08742716.7申请日： 2008-04-10
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公开(公告)号： EP2155777A2公开(公告)日： 2010-02-24
- 发明人: BRANCO, Luis, M. , MATSCHINER, Alexander , ILLICK, Megan, M. , SAMPEY, Darryl, B. , GARRY, Robert, F. , BAUSCH, Daniel, G. , FAIR, Joseph, N. , GUTTIERI, Mary, C. , CASHMAN, Kathleen, A. , WILSON, Russell, B. , KULAKOSKY, Peter, C. , GESKE, F., Jon
- 申请人： The Administrators of the Tulane Educational Fund
- 申请人地址： 1430 Tulane Avenue New Orleans, LA 70112-2699 US
- 专利权人： The Administrators of the Tulane Educational Fund
- 当前专利权人： The Administrators of the Tulane Educational Fund
- 当前专利权人地址： 1430 Tulane Avenue New Orleans, LA 70112-2699 US
- 代理机构： De Clercq, Ann G. Y.
- 优先权： US922732P 20070410
- 国际公布： WO2008124176 20081016
- 主分类号： C07K14/08
- IPC分类号： C07K14/08 ; A61K38/16 ; A61K39/12
摘要：
The invention discloses compositions comprising soluble and membrane-anchored forms of Lassa virus (LASV) glycoprotein 1 (GP1), glycoprotein 2 (GP2), the glycoprotein precursor (GPC), the nucleocapsid protein (NP), and the nucleic acids encoding these proteins. This invention further relates to diagnostic and preventative methods using these compositions. Preventative methods include preparation of vaccines, as well as factors (e.g. small molecules) that inhibit LASV infectivity. Further, the invention relates to diagnostic and therapeutic antibodies including neutralizing antibodies for the prevention and treatment of infection by LASV and other arenaviruses.
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