发明公开
- 专利标题： NOVEL CRYSTALLINE FORMS OF ATOVAQUONE
- 专利标题（中）： 新型结晶的ATOVAQUONE
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申请号： EP07805631.4申请日： 2007-06-26
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公开(公告)号： EP2160376A2公开(公告)日： 2010-03-10
- 发明人: PARTHASARADHI REDDY, Bandi , RATHNAKAR REDDY, Kura , RAJI REDDY, Rapolu , MURALIDHARA REDDY, Dasari , VSV PRASAD, Valivarthi
- 申请人： Hetero Drugs Limited
- 申请人地址： Hetero House 8-3-166/7/1, Erragadda Hyderabad, Andhrapradesh. Hyderabad 500 018 IN
- 专利权人： Hetero Drugs Limited
- 当前专利权人： Hetero Drugs Limited
- 当前专利权人地址： Hetero House 8-3-166/7/1, Erragadda Hyderabad, Andhrapradesh. Hyderabad 500 018 IN
- 代理机构： Thomas, Simon
- 国际公布： WO2009001367 20081231
- 主分类号： C07C50/14
- IPC分类号： C07C50/14
摘要：
The present invention relates to two novel and stable crystalline forms of atovaquone, to the processes for their preparation and to pharmaceutical compositions comprising them. The present invention also provides crystalline particles of atovaquone having a specific surface area of from about 0.7 m2/g to about 4 m2/g, methods for the manufacture of said crystalline particles and pharmaceutical compositions comprising said crystalline particles. The present invention further provides an improved and commercially viable process for preparation of atovaquone substantially free of undesired isomeric impurity, namely cis-2-[4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone.
公开/授权文献
- EP2160376B1 NOVEL CRYSTALLINE FORMS OF ATOVAQUONE 公开/授权日：2012-09-12
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