发明公开
EP2176282A2 8-BETA-SUBSTITUTED ESTRATRIENES AS SELECTIVELY ACTIVE ESTROGENS
有权
8-β取代16.ALPHA.氟ÖSTRATRIENEAS选择性作用的环境雌激素
- 专利标题： 8-BETA-SUBSTITUTED ESTRATRIENES AS SELECTIVELY ACTIVE ESTROGENS
- 专利标题（中）： 8-β取代16.ALPHA.氟ÖSTRATRIENEAS选择性作用的环境雌激素
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申请号： EP08775031.1申请日： 2008-07-11
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公开(公告)号： EP2176282A2公开(公告)日： 2010-04-21
- 发明人: PETERS, Olaf , BRAEUER, Nico , THIEME, Ina , PRELLE, Katja , MUHN, Hans-Peter , FRITZEMEIER, Karl-Heinrich
- 申请人： Bayer Schering Pharma Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13353 Berlin DE
- 专利权人： Bayer Schering Pharma Aktiengesellschaft
- 当前专利权人： Bayer Schering Pharma Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13353 Berlin DE
- 优先权： EP07075600 20070712
- 国际公布： WO2009007454 20090115
- 主分类号： C07J1/00
- IPC分类号： C07J1/00 ; A61K31/565 ; A61P5/30
摘要：
The invention refers to 8β-substituted estra-1,3,5(10)-triene derivatives of general formula (I), their use as pharmaceutical active ingredients, which have in vitro a higher affinity to estrogen receptor preparations from rat prostates than to estrogen receptor preparations from rat uteri and in vivo a preferential action in the ovary in comparison to the uterus, their production, their therapeutic use and pharmaceutical dispensing forms that contain the new compounds.
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