发明公开
EP2181190A2 MODIFIED LECITHIN-CHOLESTEROL ACYLTRANSFERASE ENZYMES 有权
改性磷脂,胆固醇酰基转移酶酶

  • 专利标题: MODIFIED LECITHIN-CHOLESTEROL ACYLTRANSFERASE ENZYMES
  • 专利标题(中): 改性磷脂,胆固醇酰基转移酶酶
  • 申请号: EP08796592.7
    申请日: 2008-07-25
  • 公开(公告)号: EP2181190A2
    公开(公告)日: 2010-05-05
  • 发明人: ZHOU, MingyueBOONE, ThomasMEININGER, David, ParkSCHWARTZ, MargritSHAN, BeiSHEN, Wenyan
  • 申请人: Amgen, Inc
  • 申请人地址: Patent Operations, M/S 28-2-C One Amgen Center Drive Thousand Oaks, California 91320-1799 US
  • 专利权人: Amgen, Inc
  • 当前专利权人: Amgen, Inc
  • 当前专利权人地址: Patent Operations, M/S 28-2-C One Amgen Center Drive Thousand Oaks, California 91320-1799 US
  • 代理机构: Carr, Anne Marie
  • 优先权: US952007P 20070726
  • 国际公布: WO2009015314 20090129
  • 主分类号: C12N9/10
  • IPC分类号: C12N9/10 A61K38/45
MODIFIED LECITHIN-CHOLESTEROL ACYLTRANSFERASE ENZYMES
摘要:
The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
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