发明公开
EP2186402A1 Knock-out animal models for novel genes and methods of use
审中-公开
敲出Tiermodellefürneue Gene und deren Verwendung
- 专利标题： Knock-out animal models for novel genes and methods of use
- 专利标题（中）： 敲出Tiermodellefürneue Gene und deren Verwendung
-
申请号： EP09013182.2申请日： 2006-05-18
-
公开(公告)号： EP2186402A1公开(公告)日： 2010-05-19
- 发明人: Byers-Horner, Allison Anne , Combs, Katherin , Culbertson, Ling Ling , Desauvage, Frederic , Ding, Zhiyong , Edwards, Joel , Girgis, Rosemary , Junge, Harold , Junutula, Jagath Reddy , Massey, Erin Marie , McLain, Dina Rebecca , Montgomery, Chuck , Payne, Bobby Joe , Phillips, Heidi , Qian, Ni Nancy , Rangel, Carolina , Shi, Zheng-zheng , Sparks, Mary Jean , Stala, Joy , Vogel, Peter , Willis-Sevaux, Tracy Ellen , Ye, Weilan
- 申请人： Genentech, Inc. , Lexicon Pharmaceuticals, Inc.
- 申请人地址： 1 DNA Way South San Francisco CA 94080-4990 US
- 专利权人： Genentech, Inc.,Lexicon Pharmaceuticals, Inc.
- 当前专利权人： Genentech, Inc.,Lexicon Pharmaceuticals, Inc.
- 当前专利权人地址： 1 DNA Way South San Francisco CA 94080-4990 US
- 代理机构： Tollervey, Rebecca Marie
- 优先权： US687900P 20050606; US780262P 20060307
- 主分类号： A01K67/027
- IPC分类号： A01K67/027 ; C12N15/85 ; G01N33/00
摘要：
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in a PRO618 gene. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
信息查询
