发明公开
EP2190469A4 POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS
有权
多肽和多核苷酸及其作为目标分子用于生产药物和生物制剂
- 专利标题： POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS
- 专利标题（中）： 多肽和多核苷酸及其作为目标分子用于生产药物和生物制剂
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申请号： EP08829443申请日： 2008-09-03
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公开(公告)号： EP2190469A4公开(公告)日： 2011-02-16
- 发明人: LEVINE ZURIT , ROSENBERG AVI , ROTMAN GALIT , NOVIK AMIT , TOPORIK AMIR , KINAR YARON , NEMZER SERGEY , KOIFMAN CYNTHIA , BEIMAN MERAV , DASSA LIAT , WALACH SHIRA , MONTIA EVE , SAMEACH-GREENWALD SHIRLEY , PERGAM TANIA , MILO DALIT , COHEN-DAYAG ANAT , LEVY OFER , BUBIS MARINA
- 申请人： COMPUGEN LTD
- 专利权人： COMPUGEN LTD
- 当前专利权人： COMPUGEN LTD
- 优先权： US96986507 2007-09-04; US96979907 2007-09-04; US96978007 2007-09-04; US96980607 2007-09-04; US96976907 2007-09-04; US96978807 2007-09-04
- 主分类号： A61K39/00
- IPC分类号： A61K39/00
摘要：
This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against C1ORF32 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation is also provided. This invention further relates to the discovery of extracellular domains of C1ORF32 and its variants awhich are suitable targets for cancer therapy, and drug development.
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