发明公开
EP2190825A1 5- (4- (HALOALKOXY) PHENYL) PYRIMIDINE-2-AMINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS
有权
5-（4-（卤代烷氧基）苯基）嘧啶-2-胺化合物和组合物作为激酶抑制剂的
- 专利标题： 5- (4- (HALOALKOXY) PHENYL) PYRIMIDINE-2-AMINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS
- 专利标题（中）： 5-（4-（卤代烷氧基）苯基）嘧啶-2-胺化合物和组合物作为激酶抑制剂的
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申请号： EP08798168.4申请日： 2008-08-19
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公开(公告)号： EP2190825A1公开(公告)日： 2010-06-02
- 发明人: MOLTENI, Valentina , LI, Xiaolin , LIU, Xiaodong , CHIANELLI, Donatella , NABAKKA, Juliet , LOREN, Jon , YOU, Shuli
- 申请人： IRM LLC
- 申请人地址： 131 Front Street P.O. Box HM 2899 Hamilton HM LX BM
- 专利权人： IRM LLC
- 当前专利权人： IRM LLC
- 当前专利权人地址： 131 Front Street P.O. Box HM 2899 Hamilton HM LX BM
- 代理机构： Kiddle, Simon John
- 优先权： US957260P 20070822
- 国际公布： WO2009026276 20090226
- 主分类号： C07D239/42
- IPC分类号： C07D239/42 ; C07D401/12 ; C07D403/12 ; C07D413/12 ; A61K31/505 ; A61K31/506 ; A61P1/00 ; A61P7/04 ; A61P11/06
摘要：
The invention provides compounds of formula (1) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, AbI, BCR-AbI, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3. Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, Fms, KDR, c-rapor b-raf kinases.
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