发明授权
EP2190827B1 N-BENZYL-N'-ARYLCARBONYLPIPERAZINE DERIVATIVES AS LXR MODULATORS
有权
作为LXR调节剂的N-苄基-N'-芳基羰基哌嗪衍生物
- 专利标题： N-BENZYL-N'-ARYLCARBONYLPIPERAZINE DERIVATIVES AS LXR MODULATORS
- 专利标题（中）： 作为LXR调节剂的N-苄基-N'-芳基羰基哌嗪衍生物
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申请号： EP08787281.8申请日： 2008-08-18
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公开(公告)号： EP2190827B1公开(公告)日： 2011-01-12
- 发明人: HO, Koc-Kan , ROUGHTON, Andrew Laird , NEAGU, Irina , CHAN, Jui-Hsiang , ANSARI, Nasrin , MORRIS, Michelle Lee , RONG, Yajing , OHLMEYER, Michael , COOKE, Andrew John , EDWARDS, Andrew Stanley , BENNETT, David, Jonathan
- 申请人： N.V. Organon , Pharmacopeia, LLC
- 申请人地址： Kloosterstraat 6 5349 AB Oss NL
- 专利权人： N.V. Organon,Pharmacopeia, LLC
- 当前专利权人： N.V. Organon,Pharmacopeia, LLC
- 当前专利权人地址： Kloosterstraat 6 5349 AB Oss NL
- 代理机构： van Wezenbeek, Petrus M.G.F.
- 优先权： EP07114602 20070820
- 国际公布： WO2009024550 20090226
- 主分类号： C07D241/04
- IPC分类号： C07D241/04 ; C07D243/08 ; C07D261/14 ; C07D307/14 ; C07D307/52 ; C07D307/66 ; C07D309/14 ; C07D317/58 ; C07D333/20 ; C07D333/48 ; C07D295/192 ; A61K31/4965 ; A61K31/497 ; A61P9/10
摘要：
The present invention relates to N-benzyl,N' -arylcarbonylpiperazine derivatives having the general Formula (I) to pharmaceutical compositions comprising the same, and to the use of a these N-benzyl,N' -arylcarbonylpiperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterol and bile acids transport and metabolism.
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