The latency of virtual interrupt delivery in virtual machines is reduced by normalizing and exposing the virtual interrupt routing information of each VM to a privileged domain such as the VMkernel in an organized manner to enable virtual interrupt delivery that minimizes the number of VCPU hops. A computer implemented method of processing the virtual I/O request comprises receiving the virtual I/O request, responsive to completing a physical I/O corresponding to the virtual I/O request, referring to a virtual CPU set including information on a destination virtual CPU designated by the guest operating system for handling a virtual interrupt corresponding to the virtual I/O request, and generating the virtual interrupt corresponding to the virtual I/O request to the destination virtual CPU determined by referring to the virtual CPU set.