发明授权
EP2198020B1 POLYNUCLEOTIDES ALLOWING THE EXPRESSION AND SECRETION OF RECOMBINANT PSEUDO-VIRUS CONTAINING FOREIGN EPITOPES, THEIR PRODUCTION, AND USE
有权
表达和重组伪外来抗原决定基含有病毒的允许的多核苷酸，生产和使用分泌
- 专利标题： POLYNUCLEOTIDES ALLOWING THE EXPRESSION AND SECRETION OF RECOMBINANT PSEUDO-VIRUS CONTAINING FOREIGN EPITOPES, THEIR PRODUCTION, AND USE
- 专利标题（中）： 表达和重组伪外来抗原决定基含有病毒的允许的多核苷酸，生产和使用分泌
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申请号： EP08804169.4申请日： 2008-09-12
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公开(公告)号： EP2198020B1公开(公告)日： 2016-04-13
- 发明人: DENG, Qiang , MICHEL, Marie-Louise
- 申请人： Institut Pasteur , INSERM - Institut National de la Santé et de la Recherche Médicale
- 申请人地址： 25-28, rue du Docteur Roux 75015 Paris FR
- 专利权人： Institut Pasteur,INSERM - Institut National de la Santé et de la Recherche Médicale
- 当前专利权人： Institut Pasteur,INSERM - Institut National de la Santé et de la Recherche Médicale
- 当前专利权人地址： 25-28, rue du Docteur Roux 75015 Paris FR
- 代理机构： Regimbeau
- 优先权： US960091P 20070914; US136125 20080813; US136154 20080814
- 国际公布： WO2009034182 20090319
- 主分类号： C12N15/00
- IPC分类号： C12N15/00 ; C07K14/02 ; A61K39/245
摘要：
This invention provides a new approach to the design of a virus with a defective replication cycle, which can be rescued by wild type virus co-infection, and which expresses foreign antigenic epitopes that contribute to the elimination of virus infected cells and then to viral clearance. The vector of the invention, by expression of epitopes derived from common pathogens, by-passes existing tolerance of virus specific T cell responses. The vector will only replicate in virus infected cells.
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