发明授权
EP2201109B1 TRUNCATED SECRETORY ASPARTYL PROTEINASE 2
有权
VERKÜRZTESEKRETORISCHE ASPARTYL-PROTEINASE 2
- 专利标题： TRUNCATED SECRETORY ASPARTYL PROTEINASE 2
- 专利标题（中）： VERKÜRZTESEKRETORISCHE ASPARTYL-PROTEINASE 2
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申请号： EP08802426.0申请日： 2008-09-19
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公开(公告)号： EP2201109B1公开(公告)日： 2012-10-03
- 发明人: ZURBRIGGEN, Rinaldo , DE BERNARDIS, Flavia , CASSONE, Antonio , RASI, Silvia
- 申请人： Pevion Biotech Ltd. , Istituto Superiore di Sanità
- 申请人地址： Worblentalstrasse 32 3063 Ittigen / Bern CH
- 专利权人： Pevion Biotech Ltd.,Istituto Superiore di Sanità
- 当前专利权人： Pevion Biotech Ltd.,Istituto Superiore di Sanità
- 当前专利权人地址： Worblentalstrasse 32 3063 Ittigen / Bern CH
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser
- 优先权： EP07018420 20070919
- 国际公布： WO2009036997 20090326
- 主分类号： C12N9/60
- IPC分类号： C12N9/60 ; C12N15/57 ; A61K39/00 ; A61K38/48
摘要：
The present invention relates to a truncated form of the secretory aspartyl proteinase 2 (Sap2), as well as to nucleic acid molecules encoding same. This truncated Sap2 polypeptide (tSap2) is surprisingly stable and devoid of enzymatic activity but retains full immunogenicity upon intravaginal administration and confers full protection against intravaginal challenge by the Candida fungus. The present invention further relates to compositions comprising tSap2 and to the use of tSap2 in the preparation of such compositions.
公开/授权文献
- EP2201109A1 TRUNCATED SECRETORY ASPARTYL PROTEINASE 2 公开/授权日：2010-06-30
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