An adaptive frame prediction method includes: using at least one block partition method to partition an MB that needs to perform intra-frame prediction; using at least one prediction mode to predict each sub-block in each block partition result and obtaining a sub-block residual of a current sub-block; selecting multiple transformation methods according to the sub-block type to transform each sub-block residual and obtain the code-rate distortion ratio of the current sub-block; performing frame prediction for the MB according to the block partition method, the prediction mode, and the transformation method corresponding to the code-rate distortion ratio of a minimum value among all code-rate distortion ratios. An adaptive prediction apparatus disclosed herein includes: a block partition module, a predicting module, a transforming module, a selecting module, and a frame predicting module. The method and the apparatus herein perform the intra-frame or inter-frame coding flexibly, get more adaptive to the local texture statistic features of the MBs, and improve the coding efficiency.