发明授权
- 专利标题： SELF-EMULSIFYING PHARMACEUTICAL COMPOSITIONS OF RHEIN OR DIACEREIN
- 专利标题（中）： 大黄酸或双醋瑞因自乳化药物组合物
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申请号： EP08807835.7申请日： 2008-09-27
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公开(公告)号： EP2207531B1公开(公告)日： 2012-04-04
- 发明人: NAKHAT, PREMCHAND , MANDAOGADE, PRASHANT , JAIN, GIRISH KUMAR , TALWAR, MUNISH
- 申请人： Wockhardt Limited
- 申请人地址： D-4, MIDC Industrial Area Chikalthana Aurangabad 431210 IN
- 专利权人： Wockhardt Limited
- 当前专利权人： Wockhardt Limited
- 当前专利权人地址： D-4, MIDC Industrial Area Chikalthana Aurangabad 431210 IN
- 代理机构： May, Mark Andrew
- 优先权： INMU18952007 20070927; INMU05762008 20080324; INMU11152008 20080526
- 国际公布： WO2009040776 20090402
- 主分类号： A61K9/107
- IPC分类号： A61K9/107 ; A61K9/48 ; A61K47/44 ; A61K31/222
摘要：
The invention relates to self emulsifying drug delivery system based compositions of rhein or diacerein, or salts or esters or prodrugs thereof which are bioequivalent to a 50 mg diacerein formulation marketed under the trade name Art 50 ®. The compositions exhibit no variability in fed and fasted state conditions. The compositions also result in significant reduction in side effects such as, soft stools effects as compared to Art 50 ®. The invention also relates to methods for preparing such compositions.
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