发明公开
- 专利标题: HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF
- 专利标题(中): 杂环化合物和药物组合物
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申请号: EP08845000.2申请日: 2008-10-29
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公开(公告)号: EP2207773A2公开(公告)日: 2010-07-21
- 发明人: SUMIDA, Takumi , TABUSA, Fujio , SEKIGUCHI, Kazuo , KODAMA, Takeshi , YASUMURA, Koichi , KOJIMA, Yutaka , MOTOYAMA, Masaaki , MIYAJIMA, Keisuke , YOSHIDA, Kenji , KAN, Keizo , SAKAMOTO, Makoto , TAKASU, Hideki , NAKAGAWA, Takashi , OHI, Naoto , HARADA, Yasuo , HASHIMOTO, Norikazu , MATSUYAMA, Hironori , IIDA, Masatoshi , FUJITA, Shigekazu , FUKUSHIMA, Tae
- 申请人: Otsuka Pharmaceutical Co., Ltd.
- 申请人地址: 9, Kanda-Tsukasa-machi 2-chome Chiyoda-ku Tokyo 101-8535 JP
- 专利权人: Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人: Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人地址: 9, Kanda-Tsukasa-machi 2-chome Chiyoda-ku Tokyo 101-8535 JP
- 代理机构: HOFFMANN EITLE
- 优先权: JP2007281601 20071030; JP2007336157 20071227
- 国际公布: WO2009057811 20090507
- 主分类号: C07D401/12
- IPC分类号: C07D401/12 ; C07D403/12 ; A61K31/444 ; A61K31/506 ; A61P1/16
摘要:
The present invention provides a heterocyclic compound represented by General Formula (1): wherein R1 is a group R5-Z1-, etc., Z1 is a lower alkylene group, etc., and R5 is a group represented by General Formula; wherein R13 is a hydrogen atom, etc., m is an integer from 1 to 5; R2 is a hydrogen atom: Y is CH or N: A1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group -CO-, etc.: R3 is a hydrogen atom, etc.: R4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R3 and R4, together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.
公开/授权文献
- EP2207773B1 HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF 公开/授权日:2012-07-11
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