发明授权
- 专利标题： METHOD FOR OPENING TIGHT JUNCTIONS
- 专利标题（中）： 程序用于打开密封连接
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申请号： EP08837274.3申请日： 2008-10-13
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公开(公告)号： EP2209894B1公开(公告)日： 2015-06-03
- 发明人: HUMPHRIES, Peter , CAMPBELL, Matthew , KIANG, Anna-Sophia
- 申请人： The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin
- 申请人地址： College Green Dublin 2 IE
- 专利权人： The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin
- 当前专利权人： The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin
- 当前专利权人地址： College Green Dublin 2 IE
- 代理机构： Hally, Anna-Louise
- 优先权： EP07118412 20071012; IE20080743 20080912
- 国际公布： WO2009047362 20090416
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; C12N15/11
摘要：
The present invention is directed to a method and use of RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood retinal barrier. This method may be used in the treatment of many diseases and disorders which require the opening of the blood brain barrier and/or blood retinal barrier. Such methods generally involve the use of an RNAi-inducing agent, such as siRNA, miRNA, shRNA or an RNAi-inducing vector whose presence within a cell results in production of an siRNA or shRNA, targeting tight junction proteins to open the blood brain barrier and/or blood retinal barrier.
公开/授权文献
- EP2209894A2 METHOD FOR OPENING TIGHT JUNCTIONS 公开/授权日：2010-07-28
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