发明公开
EP2212311A2 MALEATE SALTS OF (E)-N-{4-Ý3-CHLORO-4-(2-PYRIDINYLMETHOXY)ANILINO¨-3-CYANO-7-ETHOXY-6-QUINOLINYL}-4-(DIMETHYLAMINO)-2-BUTENAMIDE AND CRYSTALLINE FORMS THEREOF
审中-公开
（E）-N-的马来酸盐{4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基）-2-丁烯酰胺和结晶 IT形式
- 专利标题： MALEATE SALTS OF (E)-N-{4-Ý3-CHLORO-4-(2-PYRIDINYLMETHOXY)ANILINO¨-3-CYANO-7-ETHOXY-6-QUINOLINYL}-4-(DIMETHYLAMINO)-2-BUTENAMIDE AND CRYSTALLINE FORMS THEREOF
- 专利标题（中）： （E）-N-的马来酸盐{4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基）-2-丁烯酰胺和结晶 IT形式
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申请号： EP08840120.3申请日： 2008-10-16
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公开(公告)号： EP2212311A2公开(公告)日： 2010-08-04
- 发明人: LU, Qinghong , KU, Mannching, Sherry , CHEW, Warren , CHEAL, Gloria, K. , HADFIELD, Anthony, F. , MIRMEHRABI, Mahmoud
- 申请人： Wyeth LLC
- 申请人地址： Five Giralda Farms Madison, NJ 07940 US
- 专利权人： Wyeth LLC
- 当前专利权人： Wyeth LLC
- 当前专利权人地址： Five Giralda Farms Madison, NJ 07940 US
- 代理机构： Ricol, David Gerard
- 优先权： US124796 20071017
- 国际公布： WO2009052264 20090423
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; A61K31/404 ; A61P35/00
摘要：
The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, (NERATINIB) methods of preparing crystalline maleate salt forms, the associated compounds, such as its degradation and impurities and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
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