A solution is proposed for controlling a bookbinding folding/sewing combined machine. A corresponding method (500) includes the steps of gathering (566) printed sheets in succession from a stack of sheets being supplied to the combined machine for obtaining groups of sheets, folding (572) the groups of sheets for obtaining corresponding signatures, and sewing (575) groups of signatures through continuous threads for obtaining corresponding book blocks. In the solution according to an embodiment of the invention, there arc further provided the steps of reading (509-521) configuration information from at least part of the sheets, causing (569-572) the folding of a current group of sheets to which a current sheet being just gathered has been added for obtaining a corresponding current signature in response to the reading of an end of signature indicator in the configuration information of the current sheet, and causing (578-581) the cutting of the threads of a current group of signatures to which the current signature has been sewn for obtaining a corresponding current book block in response to the reading of an end of book indicator in the configuration information of the current sheet.